Accession 210
Title Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach
Summary we investigated the activity of novel, isoform-selective PI3K inhibitors that target different isoforms of the p110-kDa subunit. Western blot and reverse phase protein array analyses consistently demonstrated that PIK-90 and PI-103 inhibited phosphorylation of Akt and S6, whereas p110delta or p110beta/p110delta inhibitors were less effective.
Journal Blood
Publish date March, 2009
Corresponding Author Burger JA
Array Type Reverse phase protein array
Raw data link No relevant experiment link!
Link to PubMed

PubMed ID:19318683