| Accession |
210 |
| Title |
Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach |
| Summary |
we investigated the activity of novel, isoform-selective PI3K inhibitors that target different isoforms of the p110-kDa subunit. Western blot and reverse phase protein array analyses consistently demonstrated that PIK-90 and PI-103 inhibited phosphorylation of Akt and S6, whereas p110delta or p110beta/p110delta inhibitors were less effective. |
| Journal |
Blood |
| Publish date |
March, 2009 |
| Corresponding Author |
Burger JA |
| E-mail |
|
| Array Type |
Reverse phase protein array |
| Species |
|
| Raw data link |
No relevant experiment link!
|
| Link to PubMed |
PubMed ID:19318683
|
