Accession 228
Title The platelet integrin alphaIIbbeta3 binds to the RGD and AGD motifs in fibrinogen
Summary A peptide array was used to show that AGD was the minimal binding sequence in HHLGGAKQAGDV and that the receptor recognizes ligands of the form GXGDSC, where X is a hydrophobic or basic residue. This work revises our understanding of the alphaIIbbeta3 specificity and also suggests a new class of antithrombotic agents.
Journal Chem Biol.
Publish date September, 2009
Corresponding Author Milan Mrksich
Array Type Peptide array
Species Homo sapiens
Raw data link No relevant experiment link!
Link to PubMed

PubMed ID:19778727