Accession 266
Title Quantifying the sensitivities of EGF receptor (EGFR) tyrosine kinase inhibitors in drug resistant non-small cell lung cancer (NSCLC) cells using hydrogel-based peptide array
Summary In this study we used an EGFR-phosphorylatable peptide, AEEEEYFELVAKKK, immobilized within a polyacrylamide hydrogel as a substrate for profiling the activation status of EGFR in the cellular extracts of erlotinib-resistant cancer cells. The hydrogel array was able to detect therapeutic resistance as well as identify inhibitors capable of combating therapeutic resistance.
Journal Biosens Bioelectron
Publish date August, 2010
Corresponding Author Sean P. Palecek
Array Type Technological development of protein array
Raw data link No relevant experiment link!
Link to PubMed

PubMed ID:20729058