Accession 275
Title Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium
Summary A reverse-phase protein array screen identified SRC3/AIB1 as one oncoprotein the level and stability of which increased when Int6 was silenced in MCF10A cells. Our data further show that Int6 binds SRC3 and its ubiquitin ligase Fbw7, thus perhaps mediating the interaction between SRC3-Fbw7 and proteasomes.
Journal Oncogene
Publish date October, 2010
Corresponding Author E C Chang
Array Type Reverse phase protein array
Species Homo sapiens
Raw data link No relevant experiment link!
Link to PubMed

PubMed ID:20890303