Accession 345
Title Monoclonal antibody-induced ErbB3 receptor internalization and degradation inhibits growth and migration of human melanoma cells
Summary In this study, we have evaluated the potential therapeutic efficacy of a set of three recently generated anti-human ErbB3 monoclonals, A2, A3 and A4, in human primary melanoma cells. Then, fine epitope mapping studies through a peptide array show that inhibiting vs. non-inhibiting antibodies have a dramatically different mode of binding to the to the receptor extracellular domain.
Journal Cell Cycle
Publish date April, 2012
Corresponding Author Gennaro Ciliberto
Array Type Peptide array
Species Homo sapiens
Raw data link No relevant experiment link!
Link to PubMed

PubMed ID:22421160