Accession 386
Title Profiling pathway-specific novel therapeutics in preclinical assessment for central nervous system atypical teratoid rhabdoid tumors (CNS ATRT): favorable activity of targeting EGFR- ErbB2 signaling with lapatinib
Summary Target modulation, antibody array analysis, drug combination and in vivo xenograft studies were performed on one of the pathway inhibitors found in this screening. Approximately 20% of agents in the library showed activity with IC(50) values of 1 μM or less and many showed IC(50) values less than 0.05 μM.
Journal Mol Oncol.
Publish date January, 2013
Corresponding Author Aru Narendran
Array Type Antibody array
Species Homo sapiens
Raw data link No relevant experiment link!
Link to PubMed

PubMed ID:23375777